Bhendi Yellow Vein Mosaic Disease in India Is Caused by Association of a DNA β Satellite with a Begomovirus

AbstractYellow vein mosaic disease is the major limitation in the production of bhendi or okra (Abelmoschus esculentus), an important vegetable crop of India. This disease is caused by a complex consisting of the monopartite begomovirus Bhendi yellow vein mosaic virus (BYVMV, family: Geminiviridae) and a small satellite DNA β component. BYVMV can systemically infect bhendi upon agroinoculation but produces only mild leaf curling in this host. DNA β induces typical symptoms of bhendi yellow vein mosaic disease (BYVMD) when co-agroinoculated with the begomovirus to bhendi. The DNA β component associated with BYVMD has a number of features in common with those reported for ageratum yellow vein disease and cotton leaf curl disease. BYVMV represents a new member of the emerging group of monopartite begomoviruses requiring a satellite component for symptom induction

What is the real impact of schooling on age of first union and age of first parenting ? New evidence from Guatemala

The ages of first union and of first parenting are of considerable interest, not only because of their implications for individual welfare and well-being over the life cycle, but also because they are strongly associated with fertility patterns that are thought to have important implications for the broader society. But the many positive associations between schooling attainment and ages of first union and first parenting do not mean that increasing education causes increases in ages of first union and first parenting. This study contributes to the literature by investigating the impact of schooling on ages of first union and first parenting using data collected over 35 years in Guatemala. It advances beyond the previous literature by (1) treating schooling as behaviorally-determined, which changes the estimated schooling impacts considerably in a number of cases, tending to result in stronger positive effects of schooling for females and weaker ones for males; (2) including other aspects of individuals'human capital and parental family background, which in some cases changes the estimated impact of schooling attainment a fair amount; and (3) including outcomes, additional to ages of first union and first parenting, such as union partner's human capital and union partner's family's social and economic status, which enriches the understanding of the multiple effects that schooling attainment has on the processes under study.Population&Development,Health Monitoring&Evaluation,Population Policies,Science Education,Scientific Research&Science Parks

The importance of women's status for child nutrition in developing countries:

"Malnutrition affects one out of every three preschool-age children living in developing countries.This disturbing, yet preventable, state of affairs causes untold suffering and, given its wide scale, presents a major obstacle to the development process.Volumes have been written about the causes of child malnutrition and the means of reducing it. But the role of women's social status in determining their children's nutritional health has gone largely unnoticed until recently. This study explores the relationship between women's status and children's nutrition in three developing regions: South Asia, Sub-Saharan Africa (SSA), and Latin America and the Caribbean (LAC)." from textChild welfare, Children Developing countries Nutrition, Women Social conditions, Gender, Health and nutrition,

Supply chain resilience and business responses to disruptions of the Covid-19 pandemic

Purpose: At its peak, the Covid-19 pandemic has created disruption to food supply chains in the UK and for the entire world. Although societal changes created some resilience within the supply chains, high volatility in demand creates supply, logistics and distribution issues. This is reflected in the economic instability of businesses and SMEs. In this paper, we explore factors behind this initial disruption in the supply chains and offer suggestions to businesses based on the established practices and theories. Design: We use mixed methods research. First, we conducted an exploratory study by collecting data from published online sources. Then we analysed possible scenarios from the available information using regression. We then conducted two interviews with UK retail sector representatives. These scenarios have been compared and contrasted to provide decision making points to businesses and supply chain players to tackle current and any future potential disruptions. Findings: Our findings from the current exploratory study inform the volatility of supply chains. We suggested some possible responses from businesses, during and after the pandemic. Value: Our regression model provides a decision-making approach to help supply chain businesses during the pandemic outbreak. Once a complete data set of Covid-19 is available, we can create a resilience model that can help businesses and supply chains

Effect of Zinc on Efficacy of Iron Supplementation in Improving Iron and Zinc Status in Women

Iron and zinc may interact in micronutrient supplements and thereby decrease efficacy. We investigated interactive effects of combined zinc and iron supplementation in a randomized controlled trial conducted in 459 Guatemalan women. Four groups were supplemented for 12 weeks: (1) weekly iron and folic acid (IFA); (2) weekly IFA and 30 mg zinc; (3) daily IFA; (4) daily IFA and 15 mg zinc. Effects were assessed by generalized linear regression. Baseline hemoglobin (Hb) concentration was 137.4 ± 15.5 g/L, 13% were anemic and 54% had zinc deficiency. Hb cconcentrations were similar by supplement type, but Hb concentrations improved significantly in anemic women at baseline (increase of 21.8 g/L). Mean percentage changes in serum ferritin were significantly higher in daily compared to weekly supplemented groups (86% versus 32%). The addition of zinc to IFA supplements had no significant impact on iron or zinc status. In conclusion, adding zinc to IFA supplements did not modify efficacy on iron status or improve zinc status, but daily supplementation was more efficacious than weekly in improving iron stores

Maternal Influenza Immunization and Reduced Likelihood of Prematurity and Small for Gestational Age Births: A Retrospective Cohort Study

In an analysis of surveillance data from the state of Georgia (US), Saad Omer and colleagues show an association between receipt of influenza vaccination among pregnant women and reduced risk of premature births

A double-blind study to determine the maximum tolerated dose of ethionamide, when administered twice-weekly to patients with pulmonary tuberculosis

ATI earlier report from this Centre (Tuber-culosis Chemotherapy Centre, Madras, 1964) showed that a fully supervised twice-weekly regimen of streptomycin plus high-dosage isoniazid was highly effective in the treatment of patients with newly-diagnosed bacteriologi-cally confirmed pulmonary tuberculosis. How-ever, this regimen involves intramuscular injections of streptomycin and may not always be easy to organize, especially in rural areas and in developing countries with limited resources. For this reason, it was decided to investigate the possibility of replacing strepto-mycin in the twice-weekly regimen by two oral drugs, namely ethionamide and PAS. Ethiona-mide was chosen since, apart from isoniazid and streptomycin, it was the most potent drug available at the time, and PAS was included with a view to enhance the efficacy of the regimen. Finally, it was decided that the patients should be given an intensive phase of daily treatment with streptomycin, PAS and isoniazid for two weeks. Experiments in the guinea-pig had shown that the size of the individual dose of a drug needed to be increased as the interval between successive doses was increased (Dickinson & Mitchison, 1966). As PAS is bulky and the dosage of isoniazid in the twice-weekly regimen was already high, namely 15 mg./kg. body-weight, it was decided to explore the possibility of increasing the dosage of ethionamide to a level higher than that usually employed (0.5— 1.0 g.) in daily regimens. An investigation was therefore undertaken to determine the maximum tolerated dose of ethionamide. when administered twice-weekly together with isonia-zid plus PAS. Since the assessment of ethio-namide intolerance is largely subjective, the study was conducted ‘double-blind’ with respect to the dosage of ethionamide

A Case Study of Human Milk Banking with Focus on the Role of IoT Sensor Technology

Human milk is the biological norm for newborn nutrition, with breast milk from the mother being recognized as the best nutritious source for infant health. When the milk is unavailable, donor human milk is the best alternative for infants with low birthweights. Growing recognition of the benefits of donor human milk has led to increasing global interest in monitoring and controlling human milk’s quality to fulfil the need for donor human milk. In response to this need, the REAMIT project proposed to adapt and apply existing innovative technology to continuously monitor and record human milk quality and signal potential milk quality issues. IoT sensors and a Big Data technology have been used to monitor conditions that may increase spoilage (such as temperature and humidity) in the transportation stage. The sensors were installed in the insulated bags used to transport the milk from the donor’s home/hospital to the human milk bank and vice versa. The temperature and humidity were collected every 30 minutes, whilst the GPS locator sent data every 2 minutes. The data are collected in the cloud using GPRS/CAT-M1 technology. An algorithm has been designed to send alerts when the milk temperature is above the pre-specified threshold specified by the organisation, i.e. above - 20°C. The experience showed evidence that IoT sensors can efficiently be used to monitor and maintain quality in supply chains of high-quality human milk. This rare product needs a high level of quality control which is possible with the support of smart technologies. The IoT technology is helping the human milk supply chain in five different aspects, namely reducing waste, assuring quality, improving availability, reducing cost and improving sustainability. This system could be extended to various supply chains of rare and precious commodities, including further medical supplies such as human blood and organs to completely avoid waste and ensure total quality in supply chains

Identifying bottlenecks in the iron and folic acid supply chain in Bihar, India: a mixed-methods study

Background: Maternal anaemia prevalence in Bihar, India remains high despite government mandated iron supplementation targeting pregnant women. Inadequate supply has been identified as a potential barrier to iron and folic acid (IFA) receipt. Our study objective was to examine the government health system’s IFA supply and distribution system and identify bottlenecks contributing to insufficient IFA supply. Methods: Primary data collection was conducted in November 2011 and July 2012 across 8 districts in Bihar, India. A cross-sectional, observational, mixed methods approach was utilized. Auxiliary Nurse Midwives were surveyed on current IFA supply and practices. In-depth interviews (n = 59) were conducted with health workers at state, district, block, health sub-centre, and village levels. Results: Overall, 44% of Auxiliary Nurse Midwives were out of IFA stock. Stock levels and supply chain practices varied greatly across districts. Qualitative data revealed specific bottlenecks impacting IFA forecasting, procurement, storage, disposal, lack of personnel, and few training opportunities for key players in the supply chain. Conclusions: Inadequate IFA supply is a major constraint to the IFA supplementation program, the extent of which varies widely across districts. Improvements at all levels of infrastructure, practices, and effective monitoring will be critical to strengthen the IFA supply chain in Bihar